Resident Evil Retribution

At the 2010 San Diego Comic-Con International Anderson and Jeremy Bolt told ShockTilYouDrop.com that a fifth Resident Evil film would be possible, saying: "We always take it one movie at a time. We put so much effort into them and it is a family affair. It is all about making the best possible movie now and then promoting well and getting it out there. Making sure it is seen in the right way. When the dust settles then you think about something else. For us, it is not a business, it is a passion. You don't want to start talking about the next baby until you make sure this one is okay." He also stated that if the 5th film became reality, he would like Leon S Kennedy  to make an appearance.

Jovovich told New York Magazine  that Anderson had started work on a sequel. She explained, "We've been talking to a lot of fans on Twitter and stuff, so it's probably going to be one of the first movies where we really talk to fans to see what they want, and what characters they want to see. It's going to be a more interactive process."

During an interview Jovovich, Boris Kodjoe, and Ali Larter all confirmed that if there was another film made they would reprise their roles, with Boris stating "Without hesitation I would say yes", and Ali Larter stating after being asked if she was onboard said "Sure, I love working with Milla and Paul"

A fifth film in the franchise has been confirmed, scheduled for release on September 14, 2012. Jovovich has been confirmed and Guillory will reprise her role as Jill Valentine.

In May 2011, Milla Jovovich confirmed filming would begin in the fall of 2011 and they plan to shoot some scenes in Tokyo, Japan. She also commented on the film's title, stating "I think it's called Resident Evil Retribution.